Blonde Cobra is a 1963 short film directed by experimental filmmaker Ken Jacobs. Footage for the unique and at the time controversial film was shot by Bob Flieshner. Marc Siegel states that the 33 minute film is "generally considered to be one of the masterpieces of the New York underground film scene", and that it is a "fascinating audio-visual testament to the tragicomic performance of the inimitable Jack Smith", who was a photographer and filmmaker and "queer muse" in New York avant-garde art in the 1960s and 1970s.

The film captures Smith wearing dresses and makeup, playing with dolls, and smoking marijuana. The film contains Smith droning and singing and wildly cooing and cackling in parts of the film. There was the confession of a nun (impersonated in a posh high-pitched voice by Smith) to lesbianism. The film features quotes such as "Why shave when I can't think of a reason for living" and "life is a sad business", quoting Greta Garbo. "Let's Call the Whole Thing Off" is then played, described as a "burlesque rendering" of Robert Siodmak's 1944 film Cobra Woman.