Different for Girls is a 1996 British/French comedy-drama film in which one of the protagonists is a transgender woman. The film is directed by Richard Spence and written by Tony Marchant, starring Rupert Graves and Steven Mackintosh.
Paul Prentice and Karl Foyle were close friends during their secondary school days. Paul used to defend Karl from the violent attacks of their classmates, who ridiculed Karl for being effeminate.
Some years later they are reunited literally by accident, when Paul, on the motorcycle he rides as a courier, runs into the cab that Karl (who has undergone gender confirmation surgery and is named Kim) is riding in. Paul is initially surprised to discover that Karl has become Kim, but asks her out to get re-acquainted.